Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.

@article{Mahata1997NovelAF,
  title={Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.},
  author={Sushil K Mahata and Daniel T. O'Connor and Manjula Mahata and Seung Hyun Yoo and Laurent Taupenot and Hongjiang Wu and B M Gill and Robert J. Parmer},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 6},
  pages={
          1623-33
        }
}
Catecholamine secretory vesicle core proteins (chromogranins) contain an activity that inhibits catecholamine release, but the identity of the responsible peptide has been elusive. Size-fractionated chromogranins antagonized nicotinic cholinergic-stimulated catecholamine secretion; the inhibitor was enriched in processed chromogranin fragments, and was liberated from purified chromogranin A. Of 15 synthetic peptides spanning approximately 80% of chromogranin A, one (bovine chromogranin A344-364… CONTINUE READING

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