Novel assays for detection of urinary KIM-1 in mouse models of kidney injury.

@article{Sabbisetti2013NovelAF,
  title={Novel assays for detection of urinary KIM-1 in mouse models of kidney injury.},
  author={Venkata S. Sabbisetti and Kazumi Ito and Chang Wang and Li Yang and Stephen C. Mefferd and Joseph V. Bonventre},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013},
  volume={131 1},
  pages={
          13-25
        }
}
Kidney injury molecule-1 (KIM-1) has been qualified by the Food and Drug Administration and European Medicines Agency as a urinary biomarker to monitor preclinical nephrotoxicity in rats and on a case-by-case basis for the translation of potentially nephrotoxic drugs into first-in human studies. Although mouse models are widely employed in preclinical studies, few urinary biomarker studies have been performed in mice due to limited urine availability and lack of sensitive assays. Here, we… CONTINUE READING

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