Novel aspects of the molecular mechanisms controlling insulin secretion.

  title={Novel aspects of the molecular mechanisms controlling insulin secretion.},
  author={Lena Eliasson and Fernando Abdulkader and Matthias Busse Sebastian Braun and Juris Galvanovskis and Michael B. Hoppa and Patrik Rorsman},
  journal={The Journal of physiology},
  volume={586 14},
Pancreatic beta-cells secrete insulin by Ca(2+)-dependent exocytosis of secretory granules. beta-cell exocytosis involves SNARE (soluble NSF-attachment protein receptor) proteins similar to those controlling neurotransmitter release and depends on the close association of L-type Ca(2+) channels and granules. In most cases, the secretory granules fuse individually but there is ultrastructural and biophysical evidence of multivesicular exocytosis. Estimates of the secretory rate in beta-cells in… CONTINUE READING