Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccines.

@article{Whaley2010NovelAT,
  title={Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccines.},
  author={Kevin J. Whaley and Justin Hanes and Robin Shattock and Richard A. Cone and David R. Friend},
  journal={Antiviral research},
  year={2010},
  volume={88 Suppl 1},
  pages={S55-66}
}
The HIV-1 epidemic remains unchecked despite existing technology; vaccines and microbicides in development may help reverse the epidemic. Reverse transcriptase inhibitors (RTIs) formulated in gels tenofovir (TFV) and IVRs (dapivirine) are under clinical development. While TFV or similar products may prove successful for HIV-1, alternatives to RTIs may provide additional benefits, e.g., broader STI prevention. Biopharmaceutical agents under development as microbicides include cyanovirin, RANTES… CONTINUE READING

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