Novel approaches to the development of targeted therapeutic agents for systemic lupus erythematosus.

@article{Sthoeger2014NovelAT,
  title={Novel approaches to the development of targeted therapeutic agents for systemic lupus erythematosus.},
  author={Zev Moshe Sthoeger and Amir Sharabi and Edna Mozes},
  journal={Journal of autoimmunity},
  year={2014},
  volume={54},
  pages={60-71}
}
Systemic lupus erythematosus (SLE) is a chronic multisystem disease in which various cell types and immunological pathways are dysregulated. Current therapies for SLE are based mainly on the use of non-specific immunosuppressive drugs that cause serious side effects. There is, therefore, an unmet need for novel therapeutic means with improved efficacy and lower toxicity. Based on recent better understanding of the pathogenesis of SLE, targeted biological therapies are under different stages of… CONTINUE READING
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