Novel approaches to targeting neuropeptide systems.

  title={Novel approaches to targeting neuropeptide systems.},
  author={B. Roques},
  journal={Trends in pharmacological sciences},
  volume={21 12},
  • B. Roques
  • Published 2000 in Trends in pharmacological sciences
Generation and/or interruption of cell signalling by neuropeptides has been shown to be essentially, although not exclusively, mediated by one or several membrane-bound enzymes, giving rise to the concept of selective versus dual enzyme inhibitors. Because most of these enzymes are zinc metallopeptidases, novel inhibitors are now being designed based on the structure of these proteins. The physiological role of neuropeptides and their relationships with other peptide systems can be investigated… CONTINUE READING
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