Novel approaches to increase resistance to acute respiratory infections

@article{Guryanova2021NovelAT,
  title={Novel approaches to increase resistance to acute respiratory infections},
  author={Svetlana V. Guryanova and N. A. Kudryashova and Anastasiya A. Kataeva and Bubusaira T. Orozbekova and Natalia V. Kolesnikova and Alexander G. Chuchalin},
  journal={RUDN Journal of Medicine},
  year={2021}
}
Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize innate immunity. Objective . The aim of this study was to investigate the effect of glucosaminylmuramyldipeptide (GMDP) on the level of expression of markers of differentiation and activation of functionally significant subpopulations of… 

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References

SHOWING 1-10 OF 62 REFERENCES

Strategies for Using Muramyl Peptides - Modulators of Innate Immunity of Bacterial Origin - in Medicine

Clinical trials of drugs based on muramyl peptides, as well as clinical efficacy of drugs mifamurtide, lycopid, liasten and polimuramil are highlighted.

COVID-19 и ревматология: так далеко, так близко

It has been shown that patients with IIRD undergoing active anti-rheumatic therapy are most likely not characterized by increased risk of respiratory or other life-threatening complications within COVID-19 compared to the general population, so unjustified “prophylactic” cancellation should nevertheless be avoided, thereby increasing the risk of relapse of major IIRD.

Dendritic cell subtypes as primary targets of vaccines: the emerging role and cross-talk of pattern recognition receptors

Ligands of the innate recognition systems emerge as new adjuvants for vaccine design, whereas manipulation of the signaling pathways mediated by these receptors offers new avenues for fine tuning immune responses and optimizing immunotherapies.

The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis

Recent advances in the understanding of innate signaling pathways are described, particularly by Toll-like receptors and nucleotide-binding domain and leucine-rich repeat containing receptors at mucosal surfaces.

Pathogenetic Therapy of Psoriasis by Muramyl Peptide

Monotherapy with muramyl peptide stopped the clinical manifestations of psoriasis and normalized the processes of cytokine-dependent regulation of the immune response and nonspecific resistance, expressed in a decreasing amount of serum antigens sCD54 to reference values.

Induction of Tolerance to Innocuous Inhaled Antigen Relies on a CCR7-Dependent Dendritic Cell-Mediated Antigen Transport to the Bronchial Lymph Node1

It is demonstrated that a CCR7-dependent migration of both CD103+ and CD103− lung dendritic cells to the bronchial lymph node (brLN) is indispensable for the induction of tolerance to innocuous Ags.

Decisions about dendritic cells: past, present, and future.

The in vivo distribution and development of a previously unrecognized white cell lineage is better understood, as is the importance of dendritic cell maturation to link innate and adaptive immunity in response to many stimuli.

Antibiotic resistance: turning evolutionary principles into clinical reality.

At the population level and at the patient level, adaptation involving bacterial physiology and host resilience is examined, and new approaches and technologies for improving diagnosis and treatment and minimizing the spread of resistance are described.

Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells

It is demonstrated that antigen transport via afferent lymphatics into the draining mesenteric lymph nodes is obligatory for oralolerance induction, inspiring new therapeutic strategies to exploit oral tolerance induction for the prevention and treatment of autoimmune diseases.
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