Novel approaches in the treatment of systemic mastocytosis.

  title={Novel approaches in the treatment of systemic mastocytosis.},
  author={Alfonso Quint{\'a}s-Cardama and Ahmed Aribi and J. C. Gal{\'a}n Cort{\'e}s and Francis J Giles and Hagop A Kantarjian and Srdan Verstovsek},
  volume={107 7},
In the absence of curative options, therapy for aggressive forms of systemic mastocytosis (SM) has relied in the use of cytoreductive agents, mainly interferon-alpha (IFN-alpha) and cladribine. However, responses are transient and only occur in a subset of patients. Gain-of-function mutations at codon 816 of the KIT protooncogene lead to constitutively active Kit receptor molecules, which are central to the pathogenesis of SM. Recent advances in the understanding of the molecular underpinnings… CONTINUE READING
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