Novel application of stem cell-derived factors for periodontal regeneration.

@article{Inukai2013NovelAO,
  title={Novel application of stem cell-derived factors for periodontal regeneration.},
  author={Takeharu Inukai and Wataru Katagiri and Ryoko Yoshimi and Masashi Osugi and Takamasa Kawai and Hideharu Hibi and Minoru Ueda},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={430 2},
  pages={
          763-8
        }
}
The effect of conditioned medium from cultured mesenchymal stem cells (MSC-CM) on periodontal regeneration was evaluated. In vitro, MSC-CM stimulated migration and proliferation of dog MSCs (dMSCs) and dog periodontal ligament cells (dPDLCs). Cytokines such as insulin-like growth factor, vascular endothelial growth factor, transforming growth factor-β1, and hepatocyte growth factor were detected in MSC-CM. In vivo, one-wall critical-size, intrabony periodontal defects were surgically created in… CONTINUE READING
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