Novel application of lentiviral vectors towards treatment of graft-versus-host disease.


Allogeneic transplantation of hematopoietic stem cells and lymphocytes is a curative treatment for malignant and non-malignant disease. However, the primary complication limiting the safety of transplantation is graft-versus-host disease (GvHD), which is mediated by donor T cells. Strategies for pre- and post-transplant manipulation of graft cells are not… (More)
DOI: 10.1517/14712590903002021