Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.

@article{Ooi2014NovelAH,
  title={Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.},
  author={Ee Lyn Ooi and Stephanie Tze Chan and N. E. Cho and Courtney Wilkins and Jessica Woodward and Meng Li and Ushio Kikkawa and Timothy L. Tellinghuisen and Michael Gale and Takeshi Saito},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 5},
  pages={1909-14}
}
In response to viral infection, the host induces over 300 IFN-stimulated genes (ISGs), which are the central component of intracellular antiviral innate immunity. Inefficient induction of ISGs contributes to poor control and persistence of hepatitis C virus infection. Therefore, further understanding of the hepatocytic ISG regulation machinery will guide us to an improved management strategy against hepatitis C virus infection. In this study, comprehensive genome-wide, high-throughput cDNA… CONTINUE READING
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