Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets.

@article{Otero2006NovelAA,
  title={Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets.},
  author={Luc{\'i}a Otero and Marisol Vieites and Luc{\'i}a Boiani and A Denicola and Carolina Rigol and Luc{\'i}a Opazo and Claudio A Olea-Azar and Juan D Maya and Antonio Morell{\'o} and R Luise Krauth-Siegel and Oscar Enrique Piro and Eduardo Castellano and Mercedes Gonz{\'a}lez and Dinorah Gambino and Hugo Cerecetto},
  journal={Journal of medicinal chemistry},
  year={2006},
  volume={49 11},
  pages={3322-31}
}
In the search for new therapeutic tools against American Trypanosomiasis palladium complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. Sixteen novel palladium (II) complexes with the formulas [PdCl2(HL)] and [Pd(L)2] were synthesized, and the crystal structure of [Pd(5-nitrofuryl-3-acroleine thiosemicarbazone)2] x 3DMSO was solved by X-ray diffraction methods. Most complexes showed higher in vitro growth inhibition activity against Trypanosoma cruzi than… CONTINUE READING
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