Novel antisense and peptide nucleic acid strategies for controlling gene expression.

@article{Braasch2002NovelAA,
  title={Novel antisense and peptide nucleic acid strategies for controlling gene expression.},
  author={Dwaine A Braasch and David R. Corey},
  journal={Biochemistry},
  year={2002},
  volume={41 14},
  pages={4503-10}
}
Antisense oligonucleotides have the potential to make revolutionary contributions to basic science and medicine. Oligonucleotides can bind mRNA and inhibit translation. Because they can be rapidly synthesized to be complementary to any sequence, they offer ideal tools for exploiting the massive amount of genome information now available. However, until recently, this potential was largely theoretical, and antisense experiments often produced inconclusive or misleading outcomes. This review will… CONTINUE READING