Novel antimigraineur dotarizine releases Ca2+ from caffeine‐sensitive Ca2+ stores of chromaffin cells

@article{Novalbos1999NovelAD,
  title={Novel antimigraineur dotarizine releases Ca2+ from caffeine‐sensitive Ca2+ stores of chromaffin cells},
  author={Jes{\'u}s Novalbos and Francisco Abad‐Santos and Pedro Zapater and Javier Alvarez and Mar{\'i}a Teresa Alonso and Mayte Montero and A. G. Garcı́a},
  journal={British Journal of Pharmacology},
  year={1999},
  volume={128}
}
The novel antimigraineur, dotarizine (30 μM), increased cytosolic Ca2+ concentration, [Ca2+]c, in fura‐2‐loaded bovine adrenal chromaffin cells. This increase was transient, reached a peak in about 2–5 min (0.53±0.07 μM; n=19) and then declined to basal levels over a further 5 min period. This transient rise of [Ca2+]c was mimicked by 1 μM thapsigargin and by 30 μM cyclopiazonic acid (CPA), but not by 30 μM flunarizine. Both thapsigargin and CPA occluded the effects of dotarizine and vice versa… Expand
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