Novel antimicrobial lipopeptides with long in vivo half-lives.

Abstract

The pharmacokinetic (PK) properties of novel lipopeptides (semi-synthetic amphomycin analogues) with potent activity against Gram-positive organisms were evaluated in mice and rats following single intravenous (i.v.) and oral administration. Following oral administration at 50mg/kg, plasma concentrations of amphomycin analogues were <0.3-0.9microg/mL… (More)
DOI: 10.1016/j.ijantimicag.2009.10.013

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