Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling

@article{Jeffrey2014NovelAE,
  title={Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling},
  author={M. Jeffrey and M. Lang and J. Gane and E. Chow and L. Zhang},
  journal={Neuroscience},
  year={2014},
  volume={257},
  pages={65-75}
}
  • M. Jeffrey, M. Lang, +2 authors L. Zhang
  • Published 2014
  • Chemistry, Medicine
  • Neuroscience
  • Progesterone is a known anticonvulsant, with its inhibitory effects generally attributed to its secondary metabolite, 5α,3α-tetrahydroprogesterone (THP), and THP's enhancement of GABAA receptor activity. Accumulating evidence, however, suggests that progesterone may have non-genomic actions independent of the GABAA receptor. In this study, we explored THP/GABAA-independent anticonvulsive actions of progesterone in a mouse model of hippocampal kindling and in mouse entorhinal slices in vitro… CONTINUE READING
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