Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

@article{Lehar2015NovelAC,
  title={Novel antibody–antibiotic conjugate eliminates intracellular S. aureus},
  author={Sophie M. Lehar and Thomas H. Pillow and Min Xu and Leanna R. Staben and Kimberly K. Kajihara and Richard Vandlen and Laura DePalatis and Helga Raab and Wouter L. W. Hazenbos and J. Hiroshi Morisaki and Janice Kim and Summer Park and Martine Darwish and Byoung-Chul Lee and Hilda Hernandez and Kelly M Loyet and Patrick J. Lupardus and Rina Fong and Donghong Yan and Cécile Chalouni and Elizabeth Luis and Yana Khalfin and Emile G. Plise and Jonathan Cheong and Joseph Peter Lyssikatos and Magnus Strandh and Klaus Koefoed and Peter Sejer Andersen and Johan Flygare and Man-Wah Tan and Eric J. Brown and Sanjeev Mariathasan},
  journal={Nature},
  year={2015},
  volume={527},
  pages={323-328}
}
Staphylococcus aureus is considered to be an extracellular pathogen. However, survival of S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus enabling long-term colonization of the host and explaining clinical failures and relapses after antibiotic therapy. Here we confirm that intracellular reservoirs of S. aureus in mice comprise a virulent subset of bacteria that can establish infection even in the presence of vancomycin, and we introduce a novel… 
Antibacterial drugs: Antibody–antibiotic conjugate tracks down hidden S. aureus
  • N. Bray
  • Biology
    Nature Reviews Drug Discovery
  • 2015
TLDR
targeting intracellular S. aureus — for example with this AAC — may be a clinically relevant and effective way of preventing colonization and reducing the risk of developing chronic infections.
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The exploitation of host-directed approaches as a promising strategy going forward for novel anti-infective therapies against S. aureus infections is highlighted.
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A single dose of AAC is effective in a mouse model of bacteraemia, and is superior to the use of vancomycin, the current standard of care for MRSA infection.
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