Novel anti-ulcer alpha,beta-unsaturated lactones inhibit compound 48/80-induced mast cell degranulation.

  title={Novel anti-ulcer alpha,beta-unsaturated lactones inhibit compound 48/80-induced mast cell degranulation.},
  author={A. Penissi and Mariano E Vera and M. L. Mariani and M. Rudolph and J. P. Ce{\~n}al and J. C. de Rosas and T. Fogal and C. Tonn and L. Favier and O. Giordano and R. Piezzi},
  journal={European journal of pharmacology},
  volume={612 1-3},
  • A. Penissi, Mariano E Vera, +8 authors R. Piezzi
  • Published 2009
  • Chemistry, Medicine
  • European journal of pharmacology
  • The present study was designed to examine the effects of a sesquiterpene lactone isolated from Artemisia douglasiana Besser (dehydroleucodine), a xanthanolide sesquiterpene isolated from Xanthium cavanillesii Schouw (xanthatin) and a semisynthetic butenolide (3-benzyloxymethyl-5H-furan-2-one) on mast cell degranulation induced by compound 48/80. Peritoneal mast cells from male adult Sprague-Dawley rats were purified in Percoll, preincubated in the presence of test lactones (dehydroleucodine… CONTINUE READING
    29 Citations
    Hydroxytyrosol and oleuropein of olive oil inhibit mast cell degranulation induced by immune and non-immune pathways.
    • 17
    Inhibitory effects of atractylone on mast cell-mediated allergic reactions.
    • 12
    Pharmacological characterization of Solanum cernuum Vell.: 31-norcycloartanones with analgesic and anti-inflammatory properties
    • 9
    • PDF
    Xanthatin induces G2/M cell cycle arrest and apoptosis in human gastric carcinoma MKN-45 cells.
    • 25
    • PDF
    β‐eudesmol suppresses allergic reactions via inhibiting mast cell degranulation
    • 12


    Anti-ulcerogenic activity of xanthanolide sesquiterpenes from Xanthium cavanillesii in rats.
    • 63
    Changes in Duodenal Mast Cells in Response to Dehydroleucodine
    • 7