Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage.

Abstract

High blood pressure (HBP) is an important risk factor for cardiac, renal, and vascular dysfunction. Excess inflammation is the major pathogenic mechanism for HBP-induced target organ damage (TOD). N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), a tetrapeptide specifically degraded by angiotensin converting enzyme (ACE), reduces inflammation, fibrosis, and TOD induced… (More)
DOI: 10.1152/ajpheart.00305.2007

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@article{Sharma2008NovelAM, title={Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage.}, author={Umesh Sharma and N E Rhaleb and S. Pokharel and Pamela Harding and Saman Rasoul and Hongmei Peng and Oscar A. Carretero}, journal={American journal of physiology. Heart and circulatory physiology}, year={2008}, volume={294 3}, pages={H1226-32} }