Novel anti-inflammatory compounds from Myrsine seguinii, terpeno-benzoic acids, are inhibitors of mammalian DNA polymerases.

@article{Mizushina2000NovelAC,
  title={Novel anti-inflammatory compounds from Myrsine seguinii, terpeno-benzoic acids, are inhibitors of mammalian DNA polymerases.},
  author={Yoshiyuki Mizushina and Shintaro Miyazaki and Keisuke Ohta and Mitsuru Hirota and Kengo Sakaguchi},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1475 1},
  pages={
          1-4
        }
}
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28 Citations
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28 Citations

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Citation Type

Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases.
Some anti-chronic inflammatory compounds are DNA polymerase λ-specific inhibitors
Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors.
Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase alpha and beta.
TLDR
A new lanostane-type triterpene acid, (20xi)-3-oxolanosta-7,9(11),24-trien-21-oic acid (1; dehydrotrametenonic acid) was isolated from the epidermis of the sclerotia of Poria cocos and the structure was analyzed on the basis of spectroscopic methods.
Dehydrotrametenonic Acid and Dehydroeburiconic Acid from Poria cocos and Their Inhibitory Effects on Eukaryotic DNA Polymerase α and β
TLDR
A new lanostane-type triterpene acid, (20ξ)-3-oxolanosta-7,9(11),24-trien-21-oic acid (1; dehydrotrametenonic acid) was isolated from the epidermis of the sclerotia of Poria cocos and the structure of 1 was analyzed on the basis of spectroscopic methods.
Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases.
Paeoniflorigenone purified from Paeonia daurica roots potently inhibits viral and bacterial DNA polymerases: investigation by experimental validation and docking simulation
TLDR
It is proposed that the parts of P. daurica might be used to find new antimicrobial agents and generate supplementary material for foods and the isolated molecules with inhibitory effect may be used as new scaffold for the further modification in order to develop novel inhibitors against DNA polymerization.
Chemical properties of fatty acid derivatives as inhibitors of DNA polymerases.
TLDR
The results suggest that the inhibitory mode of action of PFOdA and PFOS is different from that mediated by the classic fatty acid inhibitors against DNA polymerase beta.
DNA Related Enzymes as Molecular Targets for Antiviral and Antitumoral Chemotherapy. A Natural Overview of the Current Perspectives.
TLDR
The findings of this review confirm the importance to find new drugs and biologically active natural products, and their potential medicinally useful benefits.
Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1.
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References

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TLDR
Investigation of the enzyme-binding properties of DNA polymerase beta and its proteolytic fragments suggests that the fomitellic acid molecule competes with the template-primer molecule on its 8 kDa binding site, binds to the site, and the fosine molecule simultaneously disturbs the substrate incorporation into the template primer.
Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum.
A mushroom fruiting body-inducing substance inhibits activities of replicative DNA polymerases.
TLDR
FIS is possibly a DNA polymerase inhibitor specific to the replicative enzyme group, and the fruiting body formation may be required for the suppression of the DNA replication or the vegetative growth of the mycelium.
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TLDR
The observed inhibitions of these polynucleotide-synthesizing enzymes by suramin seem to explain, at least in part, an as yet unknown mechanism of trypanocidal action of this drug.
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The 21-tungsto-9-antimoniate ammonium salt (HPA23), known as an antiviral agent, has been shown to be a potent inhibitor of both human and murine DNA polymerase alpha and murine DNA polymerase gamma.…
The inhibitory action of fatty acids on DNA polymerase beta.
Selective inhibition of DNA polymerase-alpha family with chemically synthesized derivatives of PHYLPA, a unique Physarum lysophosphatidic acid.
New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin.
3-Geranyl-4-hydroxy-5-(3'-methyl-2'-butenyl)benzoic acid as an anti-inflammatory compound from Myrsine seguinii.
TLDR
Results indicate that the carboxylic acid and lipophilic terpene moieties of 1 were significant structural features for anti-inflammatory activity.
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