Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies

  title={Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies},
  author={Kevin H. Chen and Masayuki Wada and Amelia E. Firor and Kevin G. Pinz and A Jares and Hua Liu and Huda Salman and Marc G. Golightly and Fengshuo Lan and Xun Jiang and Yupo Ma},
Peripheral T-cell lymphomas (PTCLS) comprise a diverse group of difficult to treat, very aggressive non-Hodgkin's lymphomas (NHLS) with poor prognoses and dismal patient outlook. Despite the fact that PTCLs comprise the majority of T-cell malignancies, the standard of care is poorly established. Chimeric antigen receptor (CAR) immunotherapy has shown in B-cell malignancies to be an effective curative option and this extends promise into treating T-cell malignancies. Because PTCLS frequently… CONTINUE READING
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