Novel antagonists of 5-HT6 and/or 5-HT7 receptors affect the brain monoamines metabolism and enhance the anti-immobility activity of different antidepressants in rats

@article{Partyka2019NovelAO,
  title={Novel antagonists of 5-HT6 and/or 5-HT7 receptors affect the brain monoamines metabolism and enhance the anti-immobility activity of different antidepressants in rats},
  author={A. Partyka and M. Jastrzębska-Więsek and L. Antkiewicz-Michaluk and J. Michaluk and A. Wesołowska},
  journal={Behavioural Brain Research},
  year={2019},
  volume={359},
  pages={9-16}
}
HighlightsPZ‐668, PZ‐1433, and ADN‐1184 showed anti‐immobility action in MED = 0.1 mg/kg.5‐HT6 and/or 5‐HT7 antagonists affected brain monoamine metabolism in different way.5‐HT6 and/or 5‐HT7 antagonists potentiated the effects of different antidepressants. Abstract The aim of the present study was to investigate and compare the ability of three novel 5‐HT6 and/or 5‐HT7 receptor antagonists as follows: PZ‐668—a preferential 5‐HT6 antagonist; PZ‐1433—a preferential 5‐HT7 antagonist; and ADN‐1184… Expand
2 Citations
The pronociceptive role of 5-HT6 receptors in ventrolateral orbital cortex in a rat formalin test model
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The results suggested that 5-HT6 receptors play a pronociceptive role in the VLO in the rat formalin test due to its activation of AC - PKA pathway, and cerebral cortical 5- HT6 receptors could be a new target to develop analgesic drugs. Expand

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