Novel angiotensin I-converting enzyme inhibitory peptide derived from bovine casein.

@article{Yamada2013NovelAI,
  title={Novel angiotensin I-converting enzyme inhibitory peptide derived from bovine casein.},
  author={Akio Yamada and Takuma Sakurai and Daisuke Ochi and Eri Mitsuyama and Koji Yamauchi and Fumiaki Abe},
  journal={Food chemistry},
  year={2013},
  volume={141 4},
  pages={3781-9}
}
Bovine lactic casein was hydrolysed using a combination of three enzymes, namely, subtilisin, bacillolysin, and trypsin, and the resulting preparation was coined CH-3. CH-3 showed angiotensin I-converting enzyme (ACE)-inhibitory activity (IC50: 74 μg/mL). A single oral administration of CH-3 led to a transient but significant decrease in the systolic blood pressure (SBP) of spontaneously hypertensive rats (SHRs), while daily oral administration of CH-3 for 28 consecutive days led to a lower… CONTINUE READING
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