Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling.

@article{Lu2010NovelAI,
  title={Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling.},
  author={Jianming Lu and Keqiang Zhang and Sangkil Nam and Richard A. Anderson and Richard Jove and Wei Wen},
  journal={Carcinogenesis},
  year={2010},
  volume={31 3},
  pages={481-8}
}
As a critical factor in the induction of angiogenesis, vascular endothelial growth factor (VEGF) has become an attractive target for anti-angiogenesis treatment. However, the side effects associated with most anti-VEGF agents limit their chronic use. Identification of naturally occurring VEGF inhibitors derived from diet is a potential alternative approach, with the advantage of known safety. To isolate natural inhibitors of VEGF, we established an in vitro tyrosine kinase assay to screen for… CONTINUE READING