Novel and promiscuous CTL epitopes in conserved regions of Gag targeted by individuals with early subtype C HIV type 1 infection from southern Africa.

@article{Masemola2004NovelAP,
  title={Novel and promiscuous CTL epitopes in conserved regions of Gag targeted by individuals with early subtype C HIV type 1 infection from southern Africa.},
  author={Agatha M. Masemola and Tumelo N. Mashishi and Greg Khoury and Helba Bredell and Maria Paximadis and Tiyani Y Mathebula and Debra Barkhan and Adrian Puren and Efthyia Vardas and Mark Colvin and Lynn Sodai Zijenah and David K. Katzenstein and Rosemary M. Musonda and Susan K Allen and Newton I. Kumwenda and Taha Basheer Taha and Glenda Elisabeth Gray and James McIntyre and Salim S. Abdool Karim and Haynes W. Sheppard and Clive M. Gray},
  journal={Journal of immunology},
  year={2004},
  volume={173 7},
  pages={4607-17}
}
Characterization of optimal CTL epitopes in Gag can provide crucial information for evaluation of candidate vaccines in populations at the epicenter of the HIV-1 epidemic. We screened 38 individuals with recent subtype C HIV-1 infection using overlapping consensus C Gag peptides and hypothesized that unique HLA-restricting alleles in the southern African… CONTINUE READING