Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy

@inproceedings{Pessina2013NovelAO,
  title={Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy},
  author={Patrizia Pessina and Daniel Cabrera and Mar{\'i}a Gabriela Alvarez Morales and Cecilia A Riquelme and Jaime Gutierrez and Antonio Serrano and Enrique Brandan and Pura Mu{\~n}oz-C{\'a}noves},
  booktitle={Skeletal Muscle},
  year={2013}
}
Fibrosis, an excessive collagen accumulation, results in scar formation, impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies, including the lethal Duchenne muscular dystrophy (DMD), which remains incurable. Substitution of muscle by fibrotic tissue also complicates gene/cell therapies for DMD. Yet, no optimal models to study muscle fibrosis are available. In the widely used mdx mouse model for DMD, extensive fibrosis develops in the diaphragm only at… CONTINUE READING
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