Novel and effective gene transfer technique for study of vascular renin angiotensin system.

@article{Morishita1993NovelAE,
  title={Novel and effective gene transfer technique for study of vascular renin angiotensin system.},
  author={Ryuichi Morishita and G H Gibbons and Yasufumi Kaneda and Takehide Ogihara and Victor J. Dzau},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={91 6},
  pages={2580-5}
}
Vascular renin angiotensin system (RAS) has been reported to exist in vascular wall. However, there is no direct evidence whether the vascular RAS per se can modulate growth of vascular smooth muscle cells (VSMC), because there is no suitable method to investigate the effect of endogenously produced vasoactive substances on growth of these cells. In this study, we transferred angiotensin-converting enzyme (ACE) and/or renin cDNAs into cultured VSMC using the efficient Sendai virus… CONTINUE READING