Novel and Gram‐Scale Green Synthesis of Flutamide

@article{Bandgar2006NovelAG,
  title={Novel and Gram‐Scale Green Synthesis of Flutamide},
  author={Babasaheb P. Bandgar and Sanjay S. Sawant},
  journal={Synthetic Communications},
  year={2006},
  volume={36},
  pages={859 - 864}
}
Abstract Isobutyric acid in the presence of cyanuric chloride and N‐methylmorpholine was converted into active ester 3 at 0–5 °C, and it was subsequently treated with 3‐aminobenzotrifluoride 4 at 25 °C to furnish corresponding amide 5. This amide finally, on nitration, produced the desired product flutamide, 2‐methyl‐N‐[4‐nitro‐3‐(trifluoromethyl)phenyl]propionamide 6 in good yield. By‐product 2,4,6‐trihydroxy‐1,3,5‐triazine 7 was converted into the useful starting material cyanuric chloride 1… 
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