Novel analogs of ghrelin: physiological and clinical implications.

  title={Novel analogs of ghrelin: physiological and clinical implications.},
  author={Heather A. Halem and John Eric Taylor and Jesse Z. Dong and Yeelana Shen and Rakesh Datta and Alfonso Abizaid and Sabrina Diano and Tam{\'a}s L. Horv{\'a}th and Philippe Zizzari and Marie-Th{\'e}r{\`e}se Bluet-Pajot and Jacques Epelbaum and Michael D. Culler},
  journal={European journal of endocrinology},
  volume={151 Suppl 1},
Ghrelin, the 28 amino acid peptide recently identified as the natural ligand for the growth hormone (GH) secretagogue (GHS) receptor, has multiple activities in addition to stimulation of GH secretion, including stimulation of feeding and weight gain. To utilize these actions for potential therapeutic benefit, we have produced analogs of human ghrelin with enhanced metabolic stability, affinity for the GHS receptor, and efficacy in stimulating weight gain. We have also discovered an analog of… CONTINUE READING


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