Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.

@article{Anzini2013NovelAA,
  title={Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.},
  author={Maurizio Anzini and Angela Di Capua and Salvatore Maria Giovanni Valenti and Simone Brogi and Michele Rovini and Germano Giuliani and Andrea Cappelli and Salvatore Vomero and Luisa Chiasserini and Alessandro Sega and Giovanna Poce and G. L. Di Giorgi and Vincenzo Calderone and Alma Martelli and Lara Testai and Lidia Sautebin and Antonietta Rossi and Simona Pace and Carla Ghelardini and Lorenzo Di Cesare Mannelli and Veronica Benetti and Antonio Giordani and Paola Anzellotti and Melania Dovizio and Paola Patrignani and Mariangela Biava},
  journal={Journal of medicinal chemistry},
  year={2013},
  volume={56 8},
  pages={3191-206}
}
A series of 3-substituted 1,5-diarylpyrroles bearing a nitrooxyalkyl side chain linked to different spacers were designed. New classes of pyrrole-derived nitrooxyalkyl inverse esters, carbonates, and ethers (7-10) as COX-2 selective inhibitors and NO donors were synthesized and are herein reported. By taking into account the metabolic conversion of… CONTINUE READING