Novel alpha- and omega-conotoxins from Conus striatus venom.

  title={Novel alpha- and omega-conotoxins from Conus striatus venom.},
  author={Cecilia A Ramilo and G C Zafaralla and L{\'a}szl{\'o} N{\'a}dasdi and Lance G Hammerland and Doju Yoshikami and William R. Gray and R Kristipati and Janakiraman Ramachandran and George Miljanich and Baldomero M Olivera},
  volume={31 41},
Three neurotoxic peptides from the venom of Conus striatus have been purified, biochemically characterized, and chemically synthesized. One of these, an acetylcholine receptor blocker designated alpha-conotoxin SII, has the sequence GCCCNPACGPNYGCGTSCS. In contrast to all other alpha-conotoxins, SII has three disulfide bonds (instead of two), has no net positive charge, and has a free C-terminus. The other two paralytic peptides are Ca channel-targeted omega-conotoxins, SVIA and SVIB. omega… CONTINUE READING


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