Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae).

@article{Asano2001NovelAI,
  title={Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae).},
  author={N. Asano and K. Yasuda and H. Kizu and A. Kato and J. Q. Fan and R. Nash and G. Fleet and R. Molyneux},
  journal={European journal of biochemistry},
  year={2001},
  volume={268 1},
  pages={
          35-41
        }
}
The extract of bark of Angylocalyx pynaertii (Leguminosae) was found to potently inhibit mammalian alpha-L-fucosidases. A thorough examination of the extract resulted in the discovery of 15 polyhydroxylated alkaloids, including the known alkaloids from seeds of this plant, 1,4-dideoxy-1,4-imino-D-arabinitol (DAB), 1-deoxymannojirimycin (DMJ) and 2,5-imino-1,2,5-trideoxy-D-mannitol (6-deoxy-DMDP). Among them, eight sugar-mimic alkaloids showed the potent inhibitory activity towards bovine… Expand
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