Novel agonist of adenosine receptor induces relaxation of corpus cavernosum in guinea pigs: an in vitro and in vivo study.

@article{Moura2015NovelAO,
  title={Novel agonist of adenosine receptor induces relaxation of corpus cavernosum in guinea pigs: an in vitro and in vivo study.},
  author={V. Moura and Allan K. N. Alencar and Jorge A Calasans-Maia and Jaqueline S da Silva and Carlos A M Fraga and G. Zapata-sudo and E. Barreiro and R. T. Sudo},
  journal={Urology},
  year={2015},
  volume={85 5},
  pages={
          1214.e17-1214.e21
        }
}
OBJECTIVE To test the relaxation effect of a new adenosine receptor agonist N-acylhydrazone derivative, 3,4-dimethoxyphenyl-N-methyl-benzoylhydrazide (LASSBio-1359), on in vitro and in vivo preparation of corpus cavernosum (CC), and its interaction with type-5 phosphodiesterase enzyme inhibitor, sildenafil. METHODS For in vitro study, an increasing concentration of LASSBio-1359 was added in the solution at the plateau isometric tension recording of isolated guinea pig CC induced by… Expand

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