Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action.

@article{Klein2002NovelAL,
  title={Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action.},
  author={Johannes T. Klein and Mathias Fasshauer and Hermann H. Klein and Manuel Benito and C. Ronald Kahn},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2002},
  volume={24 4},
  pages={
          382-8
        }
}
Adipose tissue has emerged as an important endocrine regulator of glucose metabolism and energy homeostasis. By virtue of the mitochondrial protein uncoupling protein-1 (UCP-1), brown fat additionally plays a unique role in thermoregulation. Interest has focused on this tissue not only as a target for pharmacotherapy of obesity and insulin resistance but also as an endocrine tissue with leptin secretion and high insulin sensitivity. Most studies of adipocytes have been limited either to primary… CONTINUE READING
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