Novel actions of estrogen to promote proliferation: Integration of cytoplasmic and nuclear pathways

@article{Fox2009NovelAO,
  title={Novel actions of estrogen to promote proliferation: Integration of cytoplasmic and nuclear pathways},
  author={Emily M. Fox and Josefa Andrade and Margaret A. Shupnik},
  journal={Steroids},
  year={2009},
  volume={74},
  pages={622-627}
}
Both steroids and growth factors stimulate proliferation of steroid-dependent tumor cells, and interaction between these signaling pathways occurs at several levels. Steroid receptors are classified as ligand-activated transcription factors, and steps by which they activate target gene transcription are well understood. Several steroid responses have now been functionally linked to other intracellular signaling pathways, including c-Src or tyrosine kinase receptors. Steroids such as 17beta… CONTINUE READING

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