Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.

@article{Oppegard2009NovelAC,
  title={Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.},
  author={Lisa M. Oppegard and Andrei V. Ougolkov and Doris N Luchini and Renee A. Schoon and John R. Goodell and Harneet Kaur and Daniel D Billadeau and David M. Ferguson and Hiroshi Hiasa},
  journal={European journal of pharmacology},
  year={2009},
  volume={602 2-3},
  pages={
          223-9
        }
}
We have identified a small library of novel substituted 9-aminoacridine derivatives that inhibit cell proliferation of pancreatic cancer cell lines by inducing apoptosis [Goodell, J.R. et al., 2008. J. Med. Chem. 51, 179-182.]. To further investigate their antiproliferative activities, we have assessed the antiproliferative activity of these acridine-based compounds against several pancreatic cancer cell lines. All four compounds used in this study inhibited the proliferation of pancreatic… CONTINUE READING
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Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2015
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