Novel Vitamin E Analogue Decreases Syngeneic Mouse Mammary Tumor Burden and Reduces Lung Metastasis 1

Abstract

A nonhydrolyzable ether analogue of RRRtocopherol, 2,5,7,8-tetramethyl-2R-(4R, 8R, 12trimethyltridecyl)chroman-6-yloxyacetic acid, called RRR-tocopheryloxyacetic acid or RRR-tocopherol ether-linked acetic acid analogue ( -TEA), exhibits antitumor activity in vitro and in vivo using a syngeneic BALB/c mouse mammary tumor model (line 66 clone 4 stably… (More)

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