Novel Uses for the Anabolic Androgenic Steroids Nandrolone and Oxandrolone in the Management of Male Health

  title={Novel Uses for the Anabolic Androgenic Steroids Nandrolone and Oxandrolone in the Management of Male Health},
  author={Christopher Wu and Jason R. Kovac},
  journal={Current Urology Reports},
There has recently been renewed interest in novel clinical applications of the anabolic-androgenic steroid (AAS) testosterone and its synthetic derivatives, particularly given with the rising popularity of testosterone supplementation therapy (TST) for the treatment of male hypogonadism. In this manuscript, we provide a brief review of the history of AAS and discuss clinical applications of two of the more well-known AAS: nandrolone and oxandrolone. Both agents exhibit favorable myotrophic… 

Novel Therapy for Male Hypogonadism

This review summarizes the evidence in support of commonly used treatments for male hypogonadism, as well as discuss recent updates in the development of novel therapeutics.

Anabolic-Androgenic Steroid Misuse: Mechanisms, Patterns of Misuse, User Typology, and Adverse Effects

The aim of this paper is to review the current evidence base on AAS with emphasis on mechanisms of action, adverse effects, and user profiles that are most likely to engage in AAS misuse.

Management of Anabolic Steroid-Induced Infertility: Novel Strategies for Fertility Maintenance and Recovery

Management strategies for complex patients suffering from hypogonadism are reviewed and novel medications that may be of use in this population of men are explored.

Sudden Cardiac Death in Anabolic-Androgenic Steroid Users: A Literature Review

This review aimed to focus on deaths related to AAS abuse to investigate the cardiac pathophysiological mechanism that underlies this type of death, which still needs to be fully investigated.

Androgen Treatment in Adolescent Males With Hypogonadism

The usual protocols applied for androgen therapy in boys and adolescents are discussed and Oxandrolone, a non-aromatizable drug with higher anabolic than androgenic effects, has been used in adolescents with preserved testosterone production, with positive effects on cardiometabolic health and visual, motor, and psychosocial functions.

Selective Androgen Receptor Modulators (SARMs)-Current Knowledge and Clinical Applications

SARMs have numerous possible clinical applications, with promise for the safe use in the treatment of cachexia, BPH, hypogonadism, breast cancer, and prostate cancer, as well as risks and benefits of SARMs.


A descriptive review of the seeking to understand the impact of anabolic androgenic steroid (AAs) on the human system was performed, and three possible chemical modifications in testosterone were found allowing the improvement of steroid performance as in increasing its local bioavailability, half-life and in decreasing adverse effects.

Oxandrolone Use Causes Dyslipidemia in Resistance-Training Practitioners

There was no correlation between blood and salivary parameters, but it is clear that oxandrolone causes changes in the lipid profile of users.

Medical Treatment of Hypogonadism in Men.



Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness

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    Translational andrology and urology
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An anabolic steroid, 19-nortestosterone (i.e., nandrolone, deca-durabolin) has a higher myotrophic: androgenic ratio resulting in improved effects on muscle mass and animal models have suggested application in the improvement of joint healing following rotator cuff repair.

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Based on the robust tissue selectivity of SARMs over AASs, they are worth considering as a promising therapeutic option for the treatment of various muscle-wasting diseases.

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Detecting AASs misuse through the control network of the World Anti-Doping Agency (WADA) not only aims to guarantee fair conditions for athletes, but also to protect them from medical sequelae of Aass abuse.

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Anabolic steroids are being considered for the treatment of cachexia associated with chronic disease states, and to address loss of muscle mass in the elderly, but nevertheless their efficacy still needs to be demonstrated in terms of improved physical function and quality of life.