Novel Uses for the Anabolic Androgenic Steroids Nandrolone and Oxandrolone in the Management of Male Health

@article{Wu2016NovelUF,
  title={Novel Uses for the Anabolic Androgenic Steroids Nandrolone and Oxandrolone in the Management of Male Health},
  author={Christopher Wu and Jason R. Kovac},
  journal={Current Urology Reports},
  year={2016},
  volume={17},
  pages={1-7}
}
There has recently been renewed interest in novel clinical applications of the anabolic-androgenic steroid (AAS) testosterone and its synthetic derivatives, particularly given with the rising popularity of testosterone supplementation therapy (TST) for the treatment of male hypogonadism. In this manuscript, we provide a brief review of the history of AAS and discuss clinical applications of two of the more well-known AAS: nandrolone and oxandrolone. Both agents exhibit favorable myotrophic… 
View on Springer
draisistoledo.com
21 Citations
Highly Influential Citations
1
Background Citations
5

21 Citations

Novel Therapy for Male Hypogonadism

This review summarizes the evidence in support of commonly used treatments for male hypogonadism, as well as discuss recent updates in the development of novel therapeutics.

Anabolic-Androgenic Steroid Misuse: Mechanisms, Patterns of Misuse, User Typology, and Adverse Effects

The aim of this paper is to review the current evidence base on AAS with emphasis on mechanisms of action, adverse effects, and user profiles that are most likely to engage in AAS misuse.

Management of Anabolic Steroid-Induced Infertility: Novel Strategies for Fertility Maintenance and Recovery

Management strategies for complex patients suffering from hypogonadism are reviewed and novel medications that may be of use in this population of men are explored.

Sudden Cardiac Death in Anabolic-Androgenic Steroid Users: A Literature Review

This review aimed to focus on deaths related to AAS abuse to investigate the cardiac pathophysiological mechanism that underlies this type of death, which still needs to be fully investigated.

Androgen Treatment in Adolescent Males With Hypogonadism

The usual protocols applied for androgen therapy in boys and adolescents are discussed and Oxandrolone, a non-aromatizable drug with higher anabolic than androgenic effects, has been used in adolescents with preserved testosterone production, with positive effects on cardiometabolic health and visual, motor, and psychosocial functions.

Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications.

Selective Androgen Receptor Modulators (SARMs)-Current Knowledge and Clinical Applications

SARMs have numerous possible clinical applications, with promise for the safe use in the treatment of cachexia, BPH, hypogonadism, breast cancer, and prostate cancer, as well as risks and benefits of SARMs.

DISFUNÇÕES ANATOMO-FISIOLÓGICAS PROVENIENTES DO USO INDISCRIMINADO DE DERIVADOS SINTÉTICOS DA TESTOSTERONA (EAAS) / ANATOMO-PHYSIOLOGICAL DYSFUNCTIONS ARISING FROM THE INDISCRIMINATE USE OF SYNTHETIC TESTOSTERONE DERIVATIVES (AAS)

A descriptive review of the seeking to understand the impact of anabolic androgenic steroid (AAs) on the human system was performed, and three possible chemical modifications in testosterone were found allowing the improvement of steroid performance as in increasing its local bioavailability, half-life and in decreasing adverse effects.

Oxandrolone Use Causes Dyslipidemia in Resistance-Training Practitioners

There was no correlation between blood and salivary parameters, but it is clear that oxandrolone causes changes in the lipid profile of users.

Medical Treatment of Hypogonadism in Men.

References

SHOWING 1-10 OF 72 REFERENCES

Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness

  • M. PanJ. Kovac
  • Biology, Medicine
    Translational andrology and urology
  • 2016
An anabolic steroid, 19-nortestosterone (i.e., nandrolone, deca-durabolin) has a higher myotrophic: androgenic ratio resulting in improved effects on muscle mass and animal models have suggested application in the improvement of joint healing following rotator cuff repair.

Comparative safety evaluation of selective androgen receptor modulators and anabolic androgenic steroids

  • S. ChoiB. Lee
  • Biology, Medicine
    Expert opinion on drug safety
  • 2015
Based on the robust tissue selectivity of SARMs over AASs, they are worth considering as a promising therapeutic option for the treatment of various muscle-wasting diseases.

A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids.

Oxandrolone in ALS: Preliminary analysis

  • J. RosenfeldR. KingJ. Smith
  • Biology, Medicine
    Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
  • 2000
Recent studies reveal that short-term administration of oxandrolone increases net protein synthesis in the muscle of healthy subjects, suggesting a possible mechanism for the enhanced protein synthesis.

The history of the development of anabolic-androgenic steroids.

Tissue selectivity and potential clinical applications of trenbolone (17β-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity

Effects of Androgenic-Anabolic Steroids in Athletes

Although AAS administration may affect erythropoiesis and blood haemoglobin concentrations, no effect on endurance performance was observed and little data about the effects of AAS on metabolic responses during exercise training and recovery are available and, therefore, do not allow firm conclusions.

Adverse health effects of anabolic-androgenic steroids.

MECHANISMS IN ENDOCRINOLOGY: Medical consequences of doping with anabolic androgenic steroids: effects on reproductive functions.

Detecting AASs misuse through the control network of the World Anti-Doping Agency (WADA) not only aims to guarantee fair conditions for athletes, but also to protect them from medical sequelae of Aass abuse.

Pharmacology of anabolic steroids

  • A. Kicman
  • Biology, Medicine
    British journal of pharmacology
  • 2008
Anabolic steroids are being considered for the treatment of cachexia associated with chronic disease states, and to address loss of muscle mass in the elderly, but nevertheless their efficacy still needs to be demonstrated in terms of improved physical function and quality of life.
...