Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.

@article{Mendell2000NovelUO,
  title={Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.},
  author={Joshua T. Mendell and Susan M. Medghalchi and Ross Lake and Erick N. Noensie and Harry C Dietz},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 23},
  pages={8944-57}
}
Transcripts harboring premature signals for translation termination are recognized and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay (NMD). In addition to protecting cells by preventing the translation of potentially deleterious truncated peptides, studies have suggested that NMD plays a broader role in the regulation of the steady-state levels of physiologic transcripts. In Saccharomyces cerevisiae, three trans-acting factors (Upf1p to Upf3p) are… CONTINUE READING

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