Novel Thiourea Compounds as Dual-Function Microbicides

  title={Novel Thiourea Compounds as Dual-Function Microbicides},
  author={O. D'cruz and T. Venkatachalam and F. Uckun},
  booktitle={Biology of reproduction},
  • O. D'cruz, T. Venkatachalam, F. Uckun
  • Published in Biology of reproduction 2000
  • Biology, Medicine
  • Abstract Sexually active women represent the fastest growing human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome risk group. In an effort to develop a vaginal microbicidal contraceptive potentially capable of preventing HIV transmission as well as providing fertility control, we previously reported the synthesis of novel nonnucleoside inhibitors (NNIs) of HIV-1 reverse transcriptase with sperm-immobilizing activity (SIA). To gain further insight into the structure-function… CONTINUE READING
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