Novel Therapeutic Targets for Major Depressive Disorder

@article{Lazar2019NovelTT,
  title={Novel Therapeutic Targets for Major Depressive Disorder},
  author={Max A. Lazar and Roger S. McIntyre},
  journal={Neurobiology of Depression},
  year={2019}
}
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Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications
TLDR
This study aims to review emerging evidence that provide mechanistic insights between different CNS disorders, neuroinflammation and the kynurenine pathway pertinent to CNS disease pathology that have therapeutic implications for the development of selected and efficacious treatment strategies.
C-reactive protein in patients with major depressive disorder in Zagazig university hospitals.
TLDR
CRP was elevated in patients with MDD and associated with severity of MDD, which supports the previous findings that inflammatory hypothesis has a great role in major depressive disorder pathogenesis.

References

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TLDR
Novel targets for major depressive disorder are discussed to describe their potential mechanisms of action, the available clinical evidence for these targets, the limitations of available evidence as well as future research directions.
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TLDR
Of these novel targets, the most promising – and the ones for whom the most evidence exists – appear to be the ionotropic glutamate receptors, which will require health professionals to pre-emptively identify potential responders.
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