Novel Therapeutic Targets for Major Depressive Disorder

@article{Lazar2019NovelTT,
  title={Novel Therapeutic Targets for Major Depressive Disorder},
  author={Max A. Lazar and Roger S. McIntyre},
  journal={Neurobiology of Depression},
  year={2019}
}
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Basic Hypothesis and Therapeutics Targets of Depression: A Review
  • Anil . Kumar
  • Psychology, Biology
    Archives in Neurology & Neuroscience
  • 2021
TLDR
The monoamine hypothesis is based on attenuation of monoamines such as serotonin (5-HT), norepinephrine (NE) and dopamine (DA) in the brain regions (hippocampus, limbic system and frontal cortex) that can cause depression like symptoms.
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications
TLDR
This study aims to review emerging evidence that provide mechanistic insights between different CNS disorders, neuroinflammation and the kynurenine pathway pertinent to CNS disease pathology that have therapeutic implications for the development of selected and efficacious treatment strategies.
C-reactive protein in patients with major depressive disorder in Zagazig university hospitals.
TLDR
CRP was elevated in patients with MDD and associated with severity of MDD, which supports the previous findings that inflammatory hypothesis has a great role in major depressive disorder pathogenesis.

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