Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells.

@article{DiLuoffo2015NovelTF,
  title={Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells.},
  author={Micka{\"e}l Di-Luoffo and Caroline Daems and Francis Bergeron and Jacques J. Tremblay},
  journal={Biology of reproduction},
  year={2015},
  volume={93 1},
  pages={9}
}
Testosterone production by Leydig cells is a tightly regulated process requiring synchronized expression of several steroidogenic genes by numerous transcription factors. Myocyte enhancer factor 2 (MEF2) are transcription factors recently identified in somatic cells of the male gonad. In other tissues, MEF2 factors are essential regulators of organogenesis and cell differentiation. So far in the testis, MEF2 factors were found to regulate Leydig cell steroidogenesis by controlling Nr4a1 and… CONTINUE READING
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