Novel TRPM8 Antagonist Attenuates Cold Hypersensitivity after Peripheral Nerve Injury in Rats

@article{Patel2014NovelTA,
  title={Novel TRPM8 Antagonist Attenuates Cold Hypersensitivity after Peripheral Nerve Injury in Rats},
  author={Ryan Patel and Leonor Gonçalves and Robert Newman and Feng Li Jiang and Anne Goldby and Jennifer Reeve and Alan Hendrick and Martin Richard Teall and Duncan Hannah and Sarah Almond and Nicola L. Brice and Anthony Henry Dickenson},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2014},
  volume={349},
  pages={47 - 55}
}
  • Ryan Patel, Leonor Gonçalves, +9 authors A. Dickenson
  • Published 1 April 2014
  • Medicine
  • The Journal of Pharmacology and Experimental Therapeutics
Abnormal cold sensitivity is a common feature of a range of neuropathies. In the murine somatosensory system, multiple aspects of cold sensitivity are dependent on TRPM8, both short term and in response to peripheral nerve injury. The specialized nature of cold-sensitive afferents and the restricted expression of TRPM8 render it an attractive target for the treatment of cold hypersensitivity. This current study examines the effect of a novel TRPM8 antagonist (M8-An) in naive and spinal nerve… 
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Transient Receptor Potential Channels in neuropathic pain
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This review will summarize the current knowledge of the contribution of TRP channels, particularly the thermosensitive TRP, including TRPV1, TRPA1 and TRPM8 channels that play a central role in the sensitization of nociceptive transduction.
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