Novel Synthetic Monoketone Transmute Radiation-Triggered NFκB-Dependent TNFα Cross-Signaling Feedback Maintained NFκB and Favors Neuroblastoma Regression

Abstract

Recently, we demonstrated that radiation (IR) instigates the occurrence of a NFκB-TNFα feedback cycle which sustains persistent NFκB activation in neuroblastoma (NB) cells and favors survival advantage and clonal expansion. Further, we reported that curcumin targets IR-induced survival signaling and NFκB dependent hTERT mediated clonal expansion in human NB… (More)
DOI: 10.1371/journal.pone.0072464

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@inproceedings{Aravindan2013NovelSM, title={Novel Synthetic Monoketone Transmute Radiation-Triggered NFκB-Dependent TNFα Cross-Signaling Feedback Maintained NFκB and Favors Neuroblastoma Regression}, author={Sheeja Aravindan and M Kumar Natarajan and Vibhudutta Awasthi and Terence S. Herman and Natarajan Aravindan}, booktitle={PloS one}, year={2013} }