Novel Sulfated Lymphocyte Homing Receptors and Their Control by a Core1 Extension β1,3-N-Acetylglucosaminyltransferase

@article{Yeh2001NovelSL,
  title={Novel Sulfated Lymphocyte Homing Receptors and Their Control by a Core1 Extension $\beta$1,3-N-Acetylglucosaminyltransferase},
  author={Jiunn-chern Yeh and Nobuyoshi Hiraoka and Bronislawa Petryniak and Jun Nakayama and Lesley G. Ellies and David Rabuka and Ole Hindsgaul and Jamey D Marth and John B. Lowe and Minoru Fukuda},
  journal={Cell},
  year={2001},
  volume={105},
  pages={957-969}
}
L-selectin mediates lymphocyte homing by facilitating lymphocyte adhesion to addressins expressed in the high endothelial venules (HEV) of secondary lymphoid organs. Peripheral node addressin recognized by the MECA-79 antibody is apparently part of the L-selectin ligand, but its chemical nature has been undefined. We now identify a sulfated extended core1 mucin-type O-glycan, Gal beta 1-->4(sulfo-->6)GlcNAc beta 1-->3Gal beta 1-->3GalNAc, as the MECA-79 epitope. Molecular cloning of a HEV… Expand
Core 2 Branching β1,6-N-Acetylglucosaminyltransferase and High Endothelial Venule-restricted Sulfotransferase Collaboratively Control Lymphocyte Homing*
TLDR
It is suggested that LSST and Core2GlcNAcT cooperatively synthesize HEV-specific L-selectin ligands required for lymphocyte homing and play a critical role in lymphocyte trafficking during chronic inflammation. Expand
N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules
TLDR
The essential function of GlcNAc6ST-1 and Glcnac6 ST-2 in L-selectin ligand biosynthesis in high endothelial venules and their importance in immune surveillance are demonstrated. Expand
N-Acetylglucosamine 6-O-Sulfotransferase-1 Regulates Expression of L-Selectin Ligands and Lymphocyte Homing*
TLDR
It is demonstrated that GlcNAc6ST-1 is involved in lymphocyte homing in vivo, and it is indicated that Gl cNAc 6-O-sulfotransferases -2 and -2 play complementary roles, which is particularly high-lighted by its involvement in lymphocytes homing to Peyer's patches where Glc NAc6 ST-2 expression is undetectable. Expand
Model Glycosulfopeptides from P-selectin Glycoprotein Ligand-1 Require Tyrosine Sulfation and a Core 2-branched O-Glycan to Bind to L-selectin*
TLDR
It is demonstrated that L-selectin binds with high affinity to the N-terminal region of PSGL-1 through cooperative interactions with three sulfated tyrosine residues and an appropriately positioned C2-O-sLex O-glycan. Expand
Roles of sulfated glycans in lymphocyte homing.
  • H. Kawashima
  • Biology, Medicine
  • Biological & pharmaceutical bulletin
  • 2006
TLDR
Sulfated glycans are involved in both the rolling and the chemokine-induced activation steps between lymphocytes and HEV, and recent findings on the roles of sulfate glycans in both of these lymphocyte-homing steps will be reviewed. Expand
Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs.
TLDR
Cl40 was superior to MECA-79 in blocking lymphocyte-HEV interactions in both wild-type mice and mice deficient in forming O-glycans, and this superiority was more marked in human, as CL40 completely blocked lymphocyte binding to tonsillar HEVs, whereas Meca-79 inhibited only 60%. Expand
Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes.
Blood-borne lymphocyte trafficking to peripheral lymph nodes (PLNs) depends on the successful initiation of rolling interactions mediated by L-selectin binding to sialomucin ligands in highExpand
Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment
TLDR
The results demonstrate the critical function of N-glycan-linked 6-sulfo sialyl Lewis X in L-selectin-dependent lymphocyte homing and recruitment in wild-type and mutant mice. Expand
Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferase-I-deficient mice.
TLDR
It is demonstrated that beta4GalT-I is a major galactosyltransferase responsible for selectin-ligand biosynthesis and that inflammatory responses of beta4 galactose residues in beta-1,4 linkage-deficient mice are impaired because of the defect in selectIn-ligands biosynthesis. Expand
Functions of glycans revealed by gene inactivation of L-selectin ligand sulfotransferases in mice.
TLDR
In the double-knockout mice, binding of MECA-79 antibody to lymph node HEV was completely abolished, indicating that extended core 1 O-glycans containing GlcNAc-6-O-sulfate is completely diminished in those mice. Expand
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References

SHOWING 1-10 OF 81 REFERENCES
A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34.
TLDR
A novel L-selectin ligand sulfotransferase, termed LSST, is described that directs the synthesis of the 6-sulfo sialyl Lewis(x) on L- selectin counterreceptors CD34, GlyCAM-1, and MAdCam-1 and enhances L- Selectin-mediated adhesion under shear compared to nonsulfated controls. Expand
Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin
TLDR
L-selectin, a lectin-like receptor, mediates rolling of lymphocytes on high endothelial venules (HEVs) in secondary lymphoid organs by interacting with HEV ligands, candidates for which are glycosylation- dependent cell adhesion molecule 1 (GlyCAM-1), CD34, and podocalyxin. Expand
L-Selectin Ligands That Are O-glycoprotease Resistant and Distinct from MECA-79 Antigen are Sufficient for Tethering and Rolling of Lymphocytes on Human High Endothelial Venules
TLDR
A pool of O-glycoprotease-resistant sLex-like L-selectin ligands exist on human HEV that is distinct from the mucin-associated moieties recognized by MECA-79 mAb and it is postulate that these ligands may participate in lymphocyte binding to HEV. Expand
Sulfation-dependent recognition of high endothelial venules (HEV)- ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody
TLDR
This study compares the requirements for the binding of MECA 79 and LEC-IgG to HEV-ligands and identifies Sgp200, an independent molecule of approximately 200 kD in a sulfate-dependent manner that is an additional ligand for L-selectin. Expand
Structure of the O-Glycans in GlyCAM-1, an Endothelial-derived Ligand for L-selectin
TLDR
The complete structure of β-eliminated chains of GlyCAM-1 is defined using metabolic radiolabeling, plant lectin binding, and glycosidase digestions in conjunction with high pH anion-exchange chromatography. Expand
The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis
TLDR
It is demonstrated here that mice deficient in alpha(1,3) fucosyltransferase Fuc-TVII exhibit a leukocyte adhesion deficiency characterized by absent leukocytes E- and P-selectin ligand activity and deficient HEV L- selectin ligands activity. Expand
Minimal Sulfated Carbohydrates for Recognition by L-selectin and the MECA-79 Antibody*
TLDR
Surprisingly, 6′,6-disulfolactose was poorly recognized by MECA-79, a carbohydrate- and sulfate-dependent monoclonal antibody that binds competitively to L-selectin ligands, and bound preferentially to 6-sulfolactorose. Expand
Sulphation requirement for GlyCAM-1, an endothelial ligand for L-selectin
TLDR
It is reported here that GlyCAM-1 has an additional requirement for sulphate, a high endothelial venule-associated, mucin-like glycoprotein containing predominantly O-linked carbohydrate chains. Expand
L-selectin-mediated lymphocyte rolling on MAdCAM-1
TLDR
The mucosal vascular addressin MAdCAM-1, a mucosal endothelial adhesion molecule with immunoglobulin- and mucin-like domains, is a facultative ligand for L-selectin and may be uniquely adapted to support both selectin-mediated lymphocyte rolling and integrin-mediated adhesion and arrest in vivo. Expand
Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.
TLDR
It is indicated that core 2 oligosaccharide biosynthesis segregates the physiologic roles of selectins and reveal a function for the C2 GlcNAcT in myeloid homeostasis and inflammation. Expand
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