Novel Subgenotypes of Hepatitis B Virus Genotypes C and D in Papua, Indonesia

@article{Lusida2008NovelSO,
  title={Novel Subgenotypes of Hepatitis B Virus Genotypes C and D in Papua, Indonesia},
  author={Maria Inge Lusida and Victor Eka Nugrahaputra and Soetjipto and Retno Handajani and Motoko Nagano-Fujii and Mikiko Sasayama and Takako Utsumi and Hak Hotta},
  journal={Journal of Clinical Microbiology},
  year={2008},
  volume={46},
  pages={2160 - 2166}
}
ABSTRACT Eight genotypes (A to H) and nine subtypes (adw2, adw4, ayw1, ayw2, ayw3, ayw4, adrq+, adrq−, and ayr) of hepatitis B virus (HBV) have been identified worldwide. They appear to be associated with geographical distribution, virological characteristics, and possibly clinical outcomes. We performed sequence analysis of part of the S gene and the entire precore/core gene of HBV isolates obtained from HBsAg-positive blood donors in Papua Province, Indonesia. Phylogenetic analysis of the S… 
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The Relatedness between Hepatitis B Virus from Non-Papuan Blood Donors in Jayapura and the Papuan Clusters
TLDR
Many HBV isolates from non-Papuans in Jayapura belonged to the Papuan clusters, but others had different genotype-subtype patterns with frequencies dependent on ethnicity.
Novel quasi-subgenotype D2 of hepatitis B virus identified in Taiwanese aborigines
TLDR
Interestingly, six strains of genotype D formed a distinct cluster between subgenotypes D1 and D2 suggesting a novel group of HBV, provisionally proposed to designate it as novel quasi-subgenotype D2 identified in Taiwanese aborigines.
Sequence analysis of sub-genotype D hepatitis B surface antigens isolated from Jeddah, Saudi Arabia
Complete Genome Sequence and Phylogenetic Relatedness of Hepatitis B Virus Isolates in Papua, Indonesia
TLDR
Investigating the complete genome sequence of 22 strains from Papua and subjected them to molecular evolutionary analysis confirmed by complete sequence analysis that two novel HBV subgenotypes, HBV/C6 andHBV/D6, are prevalent in Papua, Indonesia.
Another novel subgenotype of hepatitis B virus genotype C from papuans of Highland origin
TLDR
The isolated life and closed social systems of highland Papuans, even though some have been moving to Jayapura, likely contribute to the formation of this unique cluster of infection with a novel subgenotype of HBV, named C11.
Identification and characterization of novel hepatitis B virus subgenotype C10 in Nusa Tenggara, Indonesia
TLDR
To further characterize HBV in this country, 18 HBV-viremic samples obtained from blood donors in Nusa Tenggara, Indonesia, were subjected to phylogenetic analysis of an 1.6-kb partial or full-length sequence.
Analysis of the full‐length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia
TLDR
An analysis of the full‐length sequence of the four HBV/C isolates that were unclassifiable into any of the 10 known HBv/C subgenotypes showed no significant evidence of recombination, indicating that NMB09075 and MRK89703 can be classified into another novel HBV or C subgenotype (C12).
Identification of Novel D11 Hepatitis B Surface Antigen Subgenotype in Jeddah, Kingdom of Saudi Arabia
TLDR
The identification of HBV/D11 novel subgenotypes in the present study suggested that further studies with a large number of subjects in previously examined and unexamined areas may lead to discovering new HBV strain genotypes and/or subgenotype circulating in Saudi Arabia.
Hepatitis B virus genotypes/subgenotypes in voluntary blood donors in Makassar, South Sulawesi, Indonesia
TLDR
HBV/B and HBV/C are dominant in Makassar, similar to most areas in Indonesia, and mutations in BCP which might be associated with severity of liver disease are less common.
A novel hepatitis B virus (HBV) subgenotype D (D8) strain, resulting from recombination between genotypes D and E, is circulating in Niger along with HBV/E strains.
TLDR
Data suggest that, in Niger, genetic variability of HBV strains is still evolving, probably reflecting ancient endemic HBV infection.
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