Novel Statistical Approach for Primary High-Throughput Screening Hit Selection

  title={Novel Statistical Approach for Primary High-Throughput Screening Hit Selection},
  author={S. Frank Yan and Hayk Asatryan and Jing Li and Yingyao Zhou},
  journal={Journal of chemical information and modeling},
  volume={45 6},
The standard activity threshold-based method (the "top X" approach), currently widely used in the high-throughput screening (HTS) data analysis, is ineffective at identifying good-quality hits. We have proposed a novel knowledge-based statistical approach, driven by the hidden structure-activity relationship (SAR) within a screening library, for primary hit selection. Application to an in-house ultrahigh-throughput screening (uHTS) campaign has demonstrated it can directly identify active… CONTINUE READING

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