Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways

@inproceedings{Wang2013NovelSP,
  title={Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways},
  author={Minli Wang and Janapriya Saha and Megumi Hada and Jennifer A. Anderson and Janice M. Pluth and Peter O’Neill and Francis A. Cucinotta},
  booktitle={Nucleic acids research},
  year={2013}
}
Cellular damage from ionizing radiation (IR) is in part due to DNA damage and reactive oxygen species, which activate DNA damage response (DDR) and cytokine signaling pathways, including the ataxia telangiectasia mutated (ATM) and transforming growth factor (TGF)β/Smad pathways. Using classic double-strand breaks (DSBs) markers, we studied the roles of Smad proteins in DDR and the crosstalk between TGFβ and ATM pathways. We observed co-localization of phospho-Smad2 (pSmad2) and Smad7 with DSB… CONTINUE READING
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