Corpus ID: 212575097

Novel Second Derivative Spectrophotometric Methods for the Quantification of Pterostilbene (An Anti- Diabetic Agent)

  title={Novel Second Derivative Spectrophotometric Methods for the Quantification of Pterostilbene (An Anti- Diabetic Agent)},
  author={Rameshwar Koritela and Mathrusri Annapurna Mukthinuthalapati and S. Josyula and R. K. Chaitanya},
October-December 2015 859 JCPS Volume 8 Issue 4 Novel Second Derivative Spectrophotometric Methods for the Quantification of Pterostilbene (An AntiDiabetic Agent) Rameshwar Koritela, Mathrusri Annapurna Mukthinuthalapati *, Sai Phani Kumar Josyula and Routhu Krishna Chaitanya Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India * Corresponding author: E-Mail: ABSTRACT Pterostilbene (trans-3,5… Expand

Figures from this paper


Determination of pterostilbene in rat plasma by a simple HPLC-UV method and its application in pre-clinical pharmacokinetic study.
A simple HPLC-UV method was developed and validated for the quantification of pterostilbene, a pharmacologically active phytoalexin in rat plasma and appeared to have better pharmacokinetic characteristics than its natural occurring analog, resveratrol. Expand
Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India.
HPLC analysis of this age old formulation of darakchasava revealed the presence of polyphenols like resveratrol and pterostilbene, now known as antioxidants, cancer chemopreventive agents, and also known to reduce mortality from coronary heart disease by increasing high density lipoproteins like cholesterol and inhibiting platelet aggregation. Expand
High-performance liquid chromatographic analysis of pterostilbene in biological fluids using fluorescence detection.
A novel and simple high-performance liquid chromatographic method was developed and applied to the study of pterostilbene pharmacokinetics in rats, which successfully determined its concentration in foodstuffs. Expand
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.
Pterostilbene was shown to be as effective as resveratrol in inhibiting electrolyte leakage caused by herbicide-induced oxidative damage, and both compounds had the same activity as alpha-tocopherol. Expand
RP - HPLC Studies on Quantitative Determination of Pterostilbene in Dragon's Blood
Objective: To establish a HPLC method for the separation and determination of pterostilbene in Drag-on's Blood. Methods: Using Phenomenex C18 reverse phase column (250 mm × 4. 6 mm, 5 μm) andExpand
Antioxidant activity of hydroxystilbene derivatives in homogeneous solution.
A comparison of these results with previously reported data on the proapoptotic activity of these stilbenoids suggests that these two properties are not correlated. Expand
Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma.
The association of PTER and QUER inhibits metastatic melanoma growth and extends host survival and the anti-metastatic mechanism involves a PTER-induced inhibition of vascular adhesion molecule 1 expression in the hepatic sinusoidal endothelium, which consequently decreases B16M-F10 cell adhesion to the endothelia through very late activation antigen 4. Expand
Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol*
The results showed that the hydroxyl group in 4′ position is not the sole determinant for antioxidant activity, and the presence of 4′-OH together with stereoisomery in the trans-conformation was absolutely required for inhibition of cell proliferation. Expand
Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells.
The data show that pterostilbene and particularly 3,5-hydroxypterostILbene are interesting antitumor natural compounds that may be useful in the treatment of resistant hematological malignancies, including imatinib, non-responsive neoplasms. Expand
Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
These naturally occurring stilbenes, known to be strong antioxidants and to have cancer chemopreventive activities, will add to the purported health benefits derived from the consumption of these small fruits. Expand