Novel Schering and ouabain-insensitive potassium-dependent proton secretion in the mouse cortical collecting duct.

@article{Petrovic2002NovelSA,
  title={Novel Schering and ouabain-insensitive potassium-dependent proton secretion in the mouse cortical collecting duct.},
  author={Snezana Petrovic and Zachary Spicer and T Greeley and Gary E. Shull and Manoocher Soleimani},
  journal={American journal of physiology. Renal physiology},
  year={2002},
  volume={282 1},
  pages={
          F133-43
        }
}
The intercalated (IC) cells of the cortical collecting duct (CCD) are important to acid-base homeostasis by secreting acid and reabsorbing bicarbonate. Acid secretion is mediated predominantly by apical membrane Schering (SCH-28080)-sensitive H(+)-K(+)- ATPase (HKA) and bafilomycin-sensitive H(+)-ATPase. The SCH-28080-sensitive HKA is believed to be the gastric HKA (HKAg). Here we examined apical membrane potassium-dependent proton secretion in IC cells of wild-type HKAg (+/+) and HKAg knockout… 
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Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms.
TLDR
These studies are the first nonpharmacological demonstration that both HKalpha(1) andHKalpha(2) contribute to H secretion in both A-type and B-type ICs in animals fed a normal diet.
Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct.
TLDR
It is concluded that H-K-ATPase-mediated H secretion in the native mouse CD is greatest in the ICs of the CCD, 2) A- and B-type ICs possess HKalpha(1) andHKalpha(2) H-k-atPase activity, and 3) the OMCD(1).
Molecular identification of Sch28080-sensitive K-ATPase activities in the mouse kidney
TLDR
Molecular origin of types I and III K-ATPases measured in collecting ducts of normal and potassium-depleted mice reflect the functional expression of gastric and colonic H,K- ATPase, respectively.
Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases.
TLDR
Results indicate that H(+),K(+)-ATPases-especially the HKα(2)-containing H( +),K-+)- ATPases play an important role in the effects of mineralocorticoids on K(+, acid-base, and Na(+) balance.
Acid/Base Regulation in Renal Epithelia by H,K-ATPases
TLDR
A recent report using a genetic approach to quantify the contribution of two a-subunit isoforms of the H,K-ATPase to acid secretion has confirmed years of pharmacological studies from many laboratories and demonstrates that both iso forms of this enzyme are normally active in the CD.
The renal H+-K+-ATPases: physiology, regulation, and structure.
TLDR
Evaluation of enzymatic functions along the nephron and collecting duct and studies in HKalpha(1) andHKalpha(2) knockout mice suggest that the H(+)-K( +)-ATPases may function to transport ions other than protons and potassium.
Regulation of the apical Cl-/HCO-3 exchanger pendrin in rat cortical collecting duct in metabolic acidosis.
TLDR
It is concluded that metabolic acidosis decreases the activity of the apical Cl(-)/HCO(3)(-) exchanger in beta-ICs of the rat CCD by reducing the expression of pendrin.
Acid-base transport by the renal distal nephron.
The functional versatility of the distal nephron is mainly due to the large cytological heterogeneity of the segment. Part of Na+ uptake by distal tubules is dependent on Na+/H+ exchanger 2 (NHE2),…
Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl(-)/HCO3(-) exchanger activity and impairs bicarbonate secretion in kidney collecting duct.
TLDR
It is concluded that Slc26a4 (pendrin) deletion impairs the secretion of bicarbonate in vivo and reduces apical Cl(-)/HCO(3)(-) exchanger activity in B-IC and non-A, non-B-IC cells in CCD.
The H+- and H+, K+-ATPases of the Collecting Duct
TLDR
The goal of this chapter is to consider the molecular properties of the plasma membrane H+-ATPase and the H+,K+- ATPases of the collecting duct.
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